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Original Articles
- Intravenous Zoledronic Acid in Elderly Patients with Benign Paroxysmal Positional Vertigo and Osteoporosis
- Dong Won Kwack, Hyemi Lee, Dong Wook Kim
- Res Vestib Sci. 2020;19(3):95-98. Published online September 15, 2020
- DOI: https://doi.org/10.21790/rvs.2020.19.3.95
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Abstract
PDF - Objectives
Benign paroxysmal positional vertigo (BPPV), a common cause of vertigo in the elderly, shares common pathogenic mechanisms with osteoporosis. We investigated the efficacy and safety of intravenous zoledronic acid in elderly patients with BPPV and osteoporosis.
Methods
We performed a 3-year observational study with elderly patients who were diagnosed with BPPV and osteoporosis. The recurrence of BPPV and changes in bone mineral densitometry (BMD) scores were evaluated one year after the administration of intravenous zoledronic acid.
Results
We enrolled 101 elderly patients with BPPV and 54 of them (53.5%) met the diagnostic criteria for osteoporosis. Intravenous zoledronic acid was administered in 51 patients. The recurrence of BPPV was observed in only two of 49 patients (4.1%) at 1 year’s follow-up. The mean lowest T-score of BMD improved from –3.23±0.51 to –3.05±0.58 (p=0.001).
Conclusions
Our study showed that the treatment of osteoporosis can be considered to prevent the recurrence of BPPV in the elderly. Further placebo-controlled studies are needed to estimate accurately the efficacy of zoledronic acid in the prevention of recurrence of BPPV in the elderly.
- Clinical Study of Benign Paroxysmal Positional Vertigo
- Chang Hee Bae, In Hyo Lee, Dong Yook Park, Jung Eun Kim, Hyuk Soon Chang, Dong Wook Kim
- Res Vestib Sci. 2010;9(3):93-99.
- 1,764 View
- 19 Download
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Abstract
PDF
- Background and Objectives: Benign paroxysmal positional vertigo (BPPV) was the most frequent peripheral type vertigo. It has been well controlled with canalith repositioning procedure. Canalith repositioning procedure provides rapid and long-lasting relief of symptoms in most patients with BPPV. However, some patients express nonspecific symptoms such as anxiety or discomfort after canalith repositioning procedure, even after the disappearance of nystagmus and vertigo. The purpose of this study is to assess type distribution of BPPV and relationship between recurrence and subjective residual dizziness after canalith repositioning procedure in patients. Materials and Methods: Ninety-five BPPV patients of 501 patients with dizziness who visited Dizziness Clinic in the Department of Otolaryngology at Soonchunhyang University Hospital from July 2005 to June 2008 were included in this study. These patients were retrospectively reviewed based on clinical charts. In the case of BPPV, repositioning procedure was performed. We analyzed the recurrence, the relationship between recurrence and subjective residual dizziness after canalith repositioning procedure. Results: Overall recurrence rate was 13.6%. Lateral canal origin was more common than posterior canal origin. All cases except 1 were recovered by canalith repositioning procedure. There was no correlation between recurrence and origin, type, subjective residual dizziness of patients. Conclusion: Patients showed various origin, type and recurrence. After the successful canalith repositioning procedure, residual subjective symptoms of patients were presented sometimes, but was no relation to recurrence. Thus, additional follow up and emotional management may be needed.
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